Female Viagra': What You Need to Know
Sildenafil was effective and well tolerated in postmenopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues.
| Parameter | Typical Value | Notes |
|---|---|---|
| Absorption | Rapid, peaks in 30-120 minutes | Food can delay absorption |
| Distribution | Widely distributed in tissues | Binds to plasma proteins |
| Metabolism | Liver CYP3A4 enzymes | Excreted mainly in feces |
| Half-life | 4-5 hours | Duration of action varies |
Objective: This study aimed to evaluate the effect of sildenafil citrate on female sexual dysfunction.
- Some studies have shown mild improvements in female sexual distress.
- The drug may help women with orgasmic disorder by increasing sensation.
- Women should report any unusual symptoms to a healthcare professional.
- Alternative treatments include counseling and hormonal therapy.
Subjects and methods: The study was conducted in the Andrology and Gynecology departments of Zagazig and Tanta University Hospitals during the period from April 2017 to August 2020.
| Precaution | Rationale | Advice |
|---|---|---|
| Medical consultation | To rule out contraindications | Always consult prior to use |
| Avoid Nitrates | Risk of severe hypotension in combination | Do not combine with nitrates |
| Monitoring Blood Pressure | Possible hypotensive effects | Check BP regularly |
| Use under medical supervision | For dosage and safety guidance | Essential for off-label use |
Fifty-two married female patients were included in this study.
- Discussions with healthcare providers are crucial before considering sildenafil.
- Female sexual dysfunction may have hormonal, psychological, or physical causes.
- Sildenafil should never be used with other medications without medical approval.
- Its use in women should be part of a broader treatment plan.
Group 200mg sildenafil citrate 1 included 26 patients, all received 50mg sildenafil on demand and group 2 included 26 patients who took placebo tablets. Results: There was no significant difference between the studied groups regarding the demographic data, and FSFI. There was significant difference between pre and post treatment of sexual dysfunction regarding the Sildenafil arm. There was no significant difference in post treatment results between the two studied groups as regard sexual dysfunction except in orgasm which showed superior improvement in the Sildenafil group.
- Some studies investigate sildenafil’s impact on vaginal blood flow.
- Psychological factors also significantly influence female sexual response.
- Not all women will experience improved sexual function with sildenafil.
- Sexual therapy remains an important treatment option.
Conclusions: Sildenafil citrate seems to be effective in treating women who could not achieve orgasm. Abbreviations: FSD: Female Sexual Dysfunction; IRB: Institutional Review Board; FSFI: female sexual function index; SPSS: Statistical Package for Social Science Female Sexual Dysfunction (FSD) is a disturbance or dysfunction in the process of desire, arousal or orgasm, which can be a symptom of a biological condition, a psychological problem, an interpersonal issue or a combination of these factors [1].
- Research shows mixed results on sildenafil's benefits for women.
- It may improve sexual satisfaction in some women.
- Not recommended for women with cardiovascular conditions.
- Using sildenafil without medical advice is risky.
Female Sexual Dysfunction is a multi-causal and a multi- dimensional medical problem that adversely affects physical health & emotional wellbeing. Also impaired sexual function can have damaging effects on the self-esteem, sense of wholeness and interpersonal relationships of women. It is often emotionally distressing and can affect reproduction or even end up with separation or divorce [2]. Selective type 5 phosphodiesterase (PDE5) inhibitors as sildenafil, which acts by inhibiting cyclic GMP specific PDE5 may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life [3].
Shop Medications
Place the medication in a safe location – one that is up and away and out of their sight and reach. Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website for more information.
Curr. Opin. Neurobiol.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Sildenafil was effective and well-tolerated in post-menopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues [4]. However, studying FSD is lacking in the literature especially in the Arab and middle east region.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Kamagra Soft Tabs | 100mg | 120 + 6 Pills | 311.78€ 296.93€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Viagra Generic | 50mg | 20 Pills | 40.52€ 38.59€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ |
In this study, we tried to prospectively assess safety and efficacy of sildenafil citrate in treating FSD. The study was conducted in the Andrology and gynecology departments of Zagazig and Tanta University Hospitals during the period from April 2017 to August 2020. Informed consents were taken from all participants. Group A contained 26 patients who received 50mg sildenafil on demand. Group B received placebo tablets and also included 26 patients. The study was prospective, double-blinded and placebo controlled.
Materials and methods
Bring sildenafil oral strips this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies. This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use. The American Society of Health-System Pharmacists, Inc.
Inclusion Criteria
represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The Institutional Review Board (IRB) provided ethical approval for this study (Institutional Review Board N° 1965) for Faculty of Medicine, Zagazig University, and Zagazig, Egypt on March 3, 2017. Married female patients complaining of sexual dysfunction for at least 6 months and not on drug therapy for the treatment of FSD. Patients with sexual dysfunction caused by local genital disorder, patients with retinal problem, patients with chronic debilitating diseases or hormonal disturbance, patients who cannot be treated with PDEs inhibitors type 5(sildenafil) as: Major hematological, renal or hepatic abnormalities, patients with major psychological disorders including major depression or psychosis, a history of stroke or myocardial infarction or any significant cardiovascular disease within the last 6 months, or concomitant treatment with nitrates. All patients in the 2 groups were subjected to: Complete history taking: age, education, occupation, residence, age of marriage, special habits, history of medical diseases, surgical history and sexual history in the previous 6 months. Thorough general and local examination was also done. Routine laboratory investigations including complete blood count liver function tests renal function tests, blood sugar and lipid profiles; were done. Evaluation questionnaire used included 25 items designed by the investigators. Only some items selected from the female sexual function index (FSFI) [5], other questions were added to suit the purpose of study. The FSFI domain has maximum possible total scores of 36 as in (Table 1). The FSFI, a 19-item questionnaire, has been developed as a brief, multidimensional self-report instrument for assessing the key dimensions of sexual function in women.
3. Downsides
The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care. Submission: October 15, 2021; Published: February 28, 2022 *Corresponding author: Mohamed Alhefnawy, Urology department, Benha University, Egypt How to cite this article: Mohamed A, Abdulla E, Mohamed A, Mohamed E, Ahmed E, et al. Efficacy of Sildenafil Citrate on Female Sexual Dysfunction in A Sample of Egyptian Females, A Prospective Placebo Controlled Study.
Cite this article
J Gynecol Women’s Health 2022: 23(1): 556105. DOI: 10.19080/JGWH.2022.23.556105 Background: Sexual dysfunction is a problem that occurs during the sexual response cycle that prevents the individual from experiencing satisfaction from sexual activity. The assessment of sexual function in women is frequently confounded by many factors, including depressed mood and other comorbid medical and psychiatric disorders. Sildenafil is selective type 5 phosphodiesterase (PDE5) inhibitors, taken orally and effective for men with erectile dysfunction. Previous studies suggested that sildenafil may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life. It is psychometrically sound, easy to administer, and has demonstrated ability to discriminate between clinical and nonclinical populations.
LinkOut - more resources
If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking sildenafil, call your doctor immediately. If you are taking sildenafil (Viagra) for erectile dysfunction, do not take any more doses of sildenafil (Viagra) or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. If you are taking sildenafil (Liqrev, Revatio) for PAH, do not stop taking your medication until you talk to your doctor. Call your doctor if you have any unusual problems while you are taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).
Professional resources
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Store the suspension at room temperature or in a refrigerator, but do not freeze it. Dispose of any unused suspension after 60 days. Keep all medication out of sight and reach of children as many containers are not child-resistant. The questionnaire described was designed and validated for assessment of female sexual function and quality of life in clinical trials or epidemiological studies.
| Drug Name | Mechanism | Approval Status | Cost per Dose | Common Side Effects |
|---|---|---|---|---|
| Sildenafil | PDE5 inhibitor | Not officially approved | $10-$20 | Headache, flushing |
| Tadalafil | Longer duration, PDE5 inhibitor | Limited use | $15-$30 | Muscle pain, headache |
| Vardenafil | Similar to sildenafil | Experimental | $12-$25 | Vision changes |
In addition, depression questionnaire was added to exclude the major psychological depressive disorder and its result put with the evaluation questionnaire as one item only (Table 2).