Understanding Dapoxetine 30mg for Premature Ejaculation
Editorial Comment on: Dapoxetine for the Treatment of Premature Ejaculation: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial in 22 CountriesEuropean UrologyVol. Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation: integrated analysis of two randomized, double-blind, placebo-controlled trials Lack of withdrawal syndrome or effects on anxiety with dapoxetine (DPX) for the treatment of premature ejaculation (PE): results from 2 phase III trials [abstract] Premature ejaculation: an observational study of men and their partners Premature ejaculation: results from a five-country European observational study Improvement in sexual satisfaction of female partners of men with premature ejaculation (PE) treated with dapoxetine (DPX) [abstract] An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation Clinical trial methodology in premature ejaculation observational, interventional, and treatment preference studies—part II—study design, outcome measures, data analysis, and reporting Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine New avenues in the pharmacological treatment of premature ejaculation Dapoxetine has no effects on hemodynamics or electrocardiographic assessments [abstract] Daxetin® is a preparation of Dapoxetine Hydrochloride which is a selective serotonin reuptake inhibitor (SSRI}.
| Medication Type | Interaction Effect | Notes |
|---|---|---|
| Other SSRIs/SNRIs | Increased Side Effects | Risk of serotonin syndrome |
| CYP3A4 inhibitors | Increased Dapoxetine levels | Potential toxicity |
| QT prolonging drugs | Additive effect | May cause heart rhythm issues |
| Alcohol | Increased sedative effects | Avoid alcohol during use |
| Monoamine oxidase inhibitors | Severe interactions | Contraindicated |
Daxetin® is indicated for the treatment of - Premature ejaculation Personal distress or interpersonal difficulty as a consequence of premature ejaculation Poor control over ejaculation Adult men (18 to 64 years of age) The recommended starting dose of Daxetin® for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg.
- Dapoxetine 30 mg may cause side effects such as nausea, dizziness, or headache.
- Avoid alcohol while taking dapoxetine to reduce the risk of adverse effects.
- It is not recommended for use in individuals with heart conditions or liver issues.
- Store the medication at room temperature away from moisture and children.
The maximum recommended dosing frequency is one dose every 24 hours.
Shipping & Delivery
Keep it where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. If you no longer need to take this medicine or it is out of date, take it to any pharmacy for safe disposal. Do not use this medicine after the expiry date. If you do experience any side effects, most of them are minor and temporary.
Looking after your medicine
However, some side effects may need medical attention. See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects. Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell. Other side effects not listed here may occur in some people. After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at By reporting side effects, you can help provide more information on the safety of this medicine. Elderly (age 65 years and over) Safety and efficacy of Dapoxetine have not been established in patients age 65 years and over as limited data are available in this population. Children and adolescents Dapoxetine is not recommended for patients under 18 years of age Patients with renal impairment No dose adjustment is required but caution is advised in patients with mild or moderate renal impairment. Dapoxetine is not recommended for use in patients with severe renal impairment. Patients with hepatic impairment No dose adjustment is required in patients with mild hepatic impairment.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Cialis Generic | 10mg | 30 + 4 Pills | 63.32€ 60.30€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Levitra Generic | 20mg | 360 + 10 Pills | 458.44€ 436.61€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ |
Dapoxetine is contraindicated in patients with moderate and severe hepatic impairment.
Use In Driving And Operating Machinery
Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines. This medicine is only available with a doctor's prescription. This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes. Do not take this medicine if you are allergic to any of these ingredients. PRILIGY 30 mg film-coated tablets are light grey, round and marked "30" inside a triangle on one side (AUST R 147946).
Less serious side effects
PRILIGY is supplied in blister packs containing 3 or 6 tablets. This leaflet was prepared in March 2024. Dalxet is a combination medication used to treat erectile dysfunction (ED) and premature ejaculation (PE) in men. Phosphodiesterase type 5 (PDE5) inhibitor + selective serotonin reuptake inhibitor (SSRI). Available in tablet form, in dapoxetine 30mg tablet various pack sizes. Pregnancy Dapoxetine is pregnancy category C.
Shipping Information
Be careful before you drive or use any machines or tools until you know how PRILIGY affects you. This medicine may cause dizziness, light-headedness, tiredness, drowsiness, fainting, having difficulty concentrating and blurred vision in some people. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous. Avoid alcohol while you are taking this medicine. The effects of alcohol, such as dizziness, drowsiness, slow reflexes or impaired judgement, may be increased if taken with PRILIGY.
Phosphodiesterase 5 inhibitors
Follow the instructions on the carton on how to take care of your medicine properly. Keep your tablets in the pack until it is time to take them. If you take the tablets out of the pack they may not keep well. Store it in a cool dry place below 25°C and away from moisture, heat or sunlight; for example, do not store it: in the bathroom or near a sink, or in the car or on window sills. Heat and dampness can destroy some medicines. Dapoxetine is not indicated for use by women.
| Country | Average Price (per tablet) | Availability | Purchase Options |
|---|---|---|---|
| USA | $1.50 - $3.00 | Widely available | Online pharmacies, local pharmacies |
| UK | £1.20 - £2.50 | Prescription required | Prescribed by doctor, online options |
| India | ₹50 - ₹150 | Over the counter possible | Online marketplaces, pharmacies |
| Australia | AUD 2.00 - AUD 4.00 | Prescription needed | Through healthcare providers |
There are no adequate and well-controlled studies of Dapoxetine in pregnant women.
| Condition | Contraindicated? | Notes |
|---|---|---|
| Heart failure | Yes | Risk of worsening symptoms |
| Liver impairment | Yes | Metabolized in the liver, caution advised |
| Use with MAO inhibitors | Yes | Causes severe interactions |
| History of syncope | Yes | Due to risk of fainting |
| Allergic reactions to SSRIs | Yes | Allergic response possible |
Lactation Dapoxetine is not indicated for use by women.
- Use of dapoxetine should be discontinued if adverse reactions are severe or persistent.
- Keep track of dosage and frequency to avoid overdose and ensure safety.
- Dapoxetine is not intended for recreational use; misuse can be harmful.
- Always keep medication out of reach of children and pets to prevent accidental ingestion.
It is not known if either Dapoxetine or its metabolites are excreted in human breast milk.
Specialised Healthcare Solutions for Unique Needs
Take 1 tablet 1-3 hours before sexual activity, as needed. Store in a cool, dry place, away from direct sunlight. – Consult a doctor before use if you have a medical condition, take medication, or are prone to priapism. – Avoid using with nitrates, alpha-blockers, or other PDE5 inhibitors. – Do not take more than the recommended dose.
Product Image
Other combination medications for ED and PE, such as Cialis + Priligy. Department of Urologic Surgery, 420 Delaware Street, SE, MMC 394, University of Minnesota, Minneapolis, MN 55455, USA DOI: 10.1016/S0140-6736(06)69695-5 External LinkAlso available on ScienceDirect External Link Dapoxetine for treatment of premature ejaculationThe LancetNovember 11, 2006 With regard to Raimo Salokangas's question about the long-term effects of dapoxetine, adverse events seen in a 9-month open-label extension study (unpublished) were consistent with those seen in the published 3-month phase III studies. In particular, reports of depression, euphoria, and psychosis while on dapoxetine 60 mg occurred in nine (0·5%), three (0·2%), and one (0·1%) of the 1774 patients enrolled in the open-label phase, respectively; they also occurred at rates similar to those seen in the dapoxetine 60 mg treatment group of the phase III studies (table). Although studies of longer dapoxetine exposure have not been done, a recently completed randomised, double-blind, placebo-controlled safety study (as yet unpublished) showed no signs of discontinuation symptoms or psychiatric effects during 2 months of continuous daily dosing of dapoxetine, followed by abrupt discontinuation of treatment. Although there are no data to rule out the possibility of emergence of new adverse effects beyond 1 year, the short half-life of dapoxetine predicts little drug accumulation with repeated daily dosing,1 and would suggest that dapoxetine is associated with a low risk of increased adverse events or the emergence of psychiatric disorders such as those mentioned above. General Dapoxetine is only indicated in men with premature ejaculation.
Contraindications of Dapoxetine
In response to Salokangas's second question, the effects of an SSRI in a man who becomes depressed subsequent to years of dapoxetine use are unknown. Antidepressant response is dependent on numerous factors, including the secondary properties of SSRIs that might contribute to differences in the efficacy and tolerability between members of this antidepressant class.2 However, it is important to note that men with psychiatric disorders were excluded from the dapoxetine clinical trials. Individuals who become depressed would be considered contraindicated for treatment with dapoxetine. I declare that I have no conflict of interest. Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview bJohnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, NJ, USA cJohnson & Johnson Pharmaceutical Services, L.L.C., Raritan, NJ, USA dAP-HP, Neuro-Urology-Andrology, Raymond Poincaré Hospital, Garches, France Accepted January 13, 2009; Published online January 22, 2009 DOI: 10.1016/j.eururo.2009.01.025 External LinkAlso available on ScienceDirect External Link Addendum to: “Dapoxetine for the Treatment of Premature Ejaculation: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial in 22 Countries” [Eur Urol 2009;55:957–68]European UrologyVol. Safety has not been established and there are no data on the ejaculation-delaying effects in men without premature ejaculation. Use with recreational drugs Patients should be advised not to use Dapoxetine in combination with recreational drugs with serotonergic activity such as ketamine, methylenedioxymethamphetamine (MOMA) and lysergic acid diethylamide (LSD) because these may lead to potentially serious reactions if combined with Dapoxetine.
- Monitor for any allergic reactions such as rash, swelling, or difficulty breathing.
- Pregnant women or those planning pregnancy should discuss alternatives with their doctor.
- Dapoxetine should be used cautiously in older adults or those with prior medical conditions.
- Always follow the guidance given by a healthcare professional regarding dosage.
- Drug Interactions with Dapoxetine Hydrochloride 60mg
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